Correction: Okomo-Adhiambo, M. et al. Neuraminidase Inhibitor Susceptibility Testing in Human Influenza Viruses: A Laboratory Surveillance Perspective. Viruses 2010, 2, 2269–2289
نویسندگان
چکیده
1 Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop G16, Atlanta, GA 30333, USA; E-Mails: [email protected] (M.O.-A.); [email protected] (K.S.); [email protected] (K.B.); [email protected] (H.T.N.); [email protected] (V.P.M.); [email protected] (T.G.S.); [email protected] (J.S.); [email protected] (A.I.K.) 2 Atlanta Research and Education Foundation, 1670 Clairmont Rd, 151F, Decatur, GA 30033, USA 3 Battelle, Century Plaza 1, 2987 Clairmont Rd, Suite 450, Atlanta, GA 30329, USA 4 Oak Ridge Institute for Science and Education, MC-100-22, P.O. Box 117, Oak Ridge, TN 37831, USA 5 Influenza and Respiratory Viruses Section, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington St., Suite H4050, Winnipeg, MB, R3E 3R2, Canada; E-Mail: [email protected]
منابع مشابه
Neuraminidase Inhibitor Susceptibility Testing in Human Influenza Viruses: A Laboratory Surveillance Perspective
Neuraminidase inhibitors (NAIs) are vital in managing seasonal and pandemic influenza infections. NAI susceptibilities of virus isolates (n = 5540) collected during the 2008-2009 influenza season were assessed in the chemiluminescent neuraminidase inhibition (NI) assay. Box-and-whisker plot analyses of log-transformed IC(50)s were performed for each virus type/subtype and NAI to identify outlie...
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Close monitoring of drug susceptibility among human influenza viruses was necessitated by widespread resistance to M2 inhibitors in influenza H1N1 (pre-pandemic and 2009 pandemic) and H3N2 viruses, and of oseltamivir resistance in pre-pandemic H1N1 viruses. The FDA-approved neuraminidase (NA) inhibitors (NAIs), oseltamivir and zanamivir, as well as investigational NAIs, peramivir and laninamivi...
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We report characteristics of oseltamivir-resistant influenza A(H1N1)pdm09 viruses and patients infected with these viruses in the United States. During 2013-14, fifty-nine (1.2%) of 4,968 analyzed US influenza A(H1N1)pdm09 viruses had the H275Y oseltamivir resistance-conferring neuraminidase substitution. Our results emphasize the need for local surveillance for neuraminidase inhibitor suscepti...
متن کاملStandardizing the influenza neuraminidase inhibition assay among United States public health laboratories conducting virological surveillance.
BACKGROUND Monitoring influenza virus susceptibility to neuraminidase (NA) inhibitors (NAIs) is vital for detecting drug-resistant variants, and is primarily assessed using NA inhibition (NI) assays, supplemented by NA sequence analysis. However, differences in NI testing methodologies between surveillance laboratories results in variability of 50% inhibitory concentration (IC50) values, which ...
متن کاملNeuraminidase inhibitor susceptibility surveillance of influenza viruses circulating worldwide during the 2011 Southern Hemisphere season
BACKGROUND Neuraminidase (NA) inhibitors (NAIs) are currently the only antivirals effective against influenza infections due to widespread resistance to M2 inhibitors. METHODS Influenza A and B viruses (n = 1079) collected worldwide between April 01, 2011, and September 30, 2011, were assessed for susceptibility to FDA-approved NAIs, oseltamivir and zanamivir, and investigational peramivir, u...
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